Here are my thoughts after the trip:
How to get there?: There is no direct flights from Brno to Lizbon. You can travel either from Vienna or Prague, I choose option from Brno with stopover in London
What I liked the most? Walking! I recommend to go for a walk in Lisbon! Why to move a bit and admire gorgeous architecture, street art, sett's mozaiks as well as adorable little stores selling literally everything, great street art pieces and will be lead to impressive traces with view of the river. These traces are perfect spots to sit down and relax. . You can walk from Marques de Pombal square (fact to remember: Marques de Pombal is national hero, who rebuild the city after earthquake in XVII century) to the Praca des Restauradores (be aware that it is quite far) or through the web of narrow streets in the old town.
Must see?: Castello de Sao Jorge.
Must eat?: sushi from Buddha bar on the tarace Jardim de São Pedro de Alcântara
Must party on?: Pink street.
Must visit?: MUDE musseum.